Some of the works are unique Chinese art forms, using jade and ceramics, and all will be backed up with videos and scale models.
A spokesman for National Museums Liverpool said: "It will be awe-inspiring, capturing the magnificence of the Imperial Court, and the world's greatest and wealthiest empire."
The exhibition, to be housed in the newly-opened wing of World Museum Liverpool, will centre on the reign of China's most famous emperor, Quianlong, who ruled from 1736-1795.
Joanna Rowlands, of NML, said: "Visitors can experience first hand what life was like at the Imperial Court."
Living With The Emperor - the working title of the exhibition - will also examine how one man met the challenges of running such a vast and multi-ethnic empire.
NML staff are working with counterparts at the Imperial Palace Museum in Beijing and Chinese scholars in Chicago to prepare the exhibition.