The lowest-ranked side still in the hat, npower League Two outfit Bradford have been dealt a tough draw against Arsenal but at least have the benefit of home advantage.
Like Leeds the Bantams have already knocked out Premier League opponents, seeing off Wigan 4-2 on penalties after their goalless draw. For an Arsenal side looking to end a trophy drought stretching back to 2005, the chance of a taking on a fourth-tier side for a place in the semi-finals must surely be an appealing one.
Aston Villa's trip to Norwich is the only all Premier League match-up in the last eight and gives Villa boss Paul Lambert another chance to face the club he left this summer. The two teams drew 1-1 in league action at the weekend.
The draw is completed by Swansea's home match against Middlesbrough. Boro earned their place in the quarter-finals with a derby victory over Sunderland in the fourth round, while Swansea defeated their former manager Brendan Rodgers' Liverpool side at Anfield.
Fixtures are due to take place on the week commencing December 10, barring Leeds versus Chelsea which is deferred until December 19 due to the latter's participation in the World Club Cup.