Ireland centre Gordon D'Arcy will miss the rest of this season's RBS 6 Nations Championship due to a foot injury.
The Leinster player is likely to be sidelined for six weeks, the Irish Rugby Football Union announced.
Ireland have already lost wing Simon Zebo (foot) for the rest of the tournament, while fly-half Jonathan Sexton (hamstring) and lock Mike McCarthy (knee ligament strain) will also miss the game against Scotland at Murrayfield on February 24.
D'Arcy experienced discomfort in his right foot following the 12-6 defeat against England in Dublin last Sunday.
"This failed to settle down before the Ireland training session on Thursday, and following a scan yesterday afternoon it was confirmed that D'Arcy has a stress injury to a bone in his foot," the IRFU said in a statement.