Leicester will be without captain Geordan Murphy for Saturday's Aviva Premiership clash against champions Harlequins at Welford Road.
And Tigers boss Richard Cockerill has revealed wing Miles Benjamin could be sidelined for the rest of this year.
Full-back Murphy suffered a knee injury during last weekend's 9-9 draw against Saracens at Wembley, but Benjamin, who joined Tigers from Worcester earlier this year, faces up to four months out recovering from a neck problem.
"Geordan has a bruised knee and will be (out for) three or four weeks," Cockerill told the Leicester Mercury.
"Unfortunately, Miles suffered a pretty nasty injury to his neck against Northampton in the A League two weeks ago which has resulted in a spinal injury.